American Conference programma - 2021
vrijdag 1 oktober
| wedstrijd | resultaat | passing leader | rushing leader | receiving leader | |
|---|---|---|---|---|---|
 |  | HOU 45, TLSA 10 | D. Brin 258 | A. McCaskill 77 | S. Crawford 101 |
zaterdag 2 oktober
| wedstrijd | resultaat | passing leader | rushing leader | receiving leader | |
|---|---|---|---|---|---|
 |  | CIN 24, ND 13 | D. Ridder 297 | J. Ford 71 | A. Pierce 144 |
 |  | TEM 34, MEM 31 | D. Mathis 322 | R. Clark 92 | A. Anderson Jr. 108 |
 |  | NAVY 34, UCF 30 | M. Keene 178 | C. Acie 85 | B. Johnson 79 |
 |  | ECU 52, TULN 29 | H. Ahlers 288 | K. Mitchell 222 | D. Watts 79 |
 |  | SMU 41, USF 17 | T. Mordecai 301 | T. Siggers 86 | J. Horn Jr. 102 |