AFC Ajax AJA 2 - 1 |  Lille LILL | FT | Johan Cruijff Arena, Nederland | N/A |
| AFC Ajax wint 4-2 in totaal |
Arsenal ARS 3 - 2 |  Benfica BEN | FT | Georgios Karaiskakis Stadium, Athens, Griekenland | N/A |
| Arsenal wint 4-3 in totaal |
Napoli NAP 2 - 1 |  Granada GCF | FT | Diego Armando Maradona, Italië | N/A |
| Granada wint 3-2 in totaal |
Rangers RAN 5 - 2 |  Antwerp ANT | FT | Ibrox Stadium, Schotland | N/A |
| Rangers wint 9-5 in totaal |
Shakhtar Donetsk SHK 1 - 0 |  Maccabi Tel-Aviv MTA | FT | Kiev Olympic Stadium, Kiev, Oekraïne | N/A |
| Shakhtar Donetsk wint 3-0 in totaal |
1899 Hoffenheim HOF 0 - 2 |  Molde MOL | FT | PreZero Arena | N/A |
| Molde wint 5-3 in totaal |
Villarreal VILL 2 - 1 |  FC Salzburg SALZ | FT | Estadio de la Cerámica, Spanje | N/A |
| Villarreal wint 4-1 in totaal |
AC Milan MIL 1 - 1 |  Red Star Belgrade RSB | FT | Giuseppe Meazza | N/A |
| AC Milan Winst met uitdoelpunten |
AS Roma ROMA 3 - 1 |  Braga BRAG | FT | Olimpico, Italië | N/A |
| AS Roma wint 5-1 in totaal |
Bayer Leverkusen LEV 0 - 2 |  Young Boys BOY | FT | BayArena, Duitsland | N/A |
| Young Boys wint 6-3 in totaal |
Club Brugge BRUG 0 - 1 |  Dynamo Kiev KIEV | FT | Jan Breydelstadion | N/A |
| Dynamo Kiev wint 2-1 in totaal |
Dinamo Zagreb ZAG 1 - 0 |  Krasnodar FCK | FT | Maksimir | N/A |
| Dinamo Zagreb wint 4-2 in totaal |
Leicester City LEI 0 - 2 |  Slavia Prague SLP | FT | King Power Stadium | N/A |
| Slavia Prague wint 2-0 in totaal |
Manchester United MAN 0 - 0 |  Real Sociedad RSO | FT | Old Trafford, Engeland | N/A |
| Manchester United wint 4-0 in totaal |
PSV PSV 2 - 1 |  Olympiakos OLY | FT | Philips Stadion, Nederland | N/A |
| Olympiakos wint 5-4 in totaal |