BuffaloSabres
- 50-23-9
- 1e in Atlantic Division
Buffalo Sabres Programma 2021-22
| DATUM | OPPONENT | RESULTAAT | W-L-OTL | Doelman | Top Presteerder |
| vr., 15 okt. | - Montreal | W5-1 | 1-0-0 | Anderson | Anderson |
| za., 16 okt. | - Arizona | W2-1 SO | 2-0-0 | Tokarski | Tokarski |
| wo., 20 okt. | - Vancouver | W5-2 | 3-0-0 | Anderson | Anderson |
| za., 23 okt. | - Boston | L4-1 | 3-1-0 | Anderson | Olofsson |
| zo., 24 okt. | bij New Jersey | L2-1 OT | 3-1-1 | Tokarski | Tokarski |
| di., 26 okt. | - Tampa Bay | W5-1 | 4-1-1 | Anderson | Anderson |
| vr., 29 okt. | bij Anaheim | W4-3 OT | 5-1-1 | Anderson | Asplund |
| zo., 31 okt. | bij Los Angeles | L3-2 | 5-2-1 | Tokarski | Olofsson |
| wo., 3 nov. | bij San Jose | L5-3 | 5-3-1 | Anderson | Skinner |
| vr., 5 nov. | bij Seattle | L5-2 | 5-4-1 | Tokarski | Cozens |
| zo., 7 nov. | - Detroit | L4-3 OT | 5-4-2 | Tokarski | Asplund |
| di., 9 nov. | bij Washington | L5-3 | 5-5-2 | Tokarski | Miller |
| za., 13 nov. | - Edmonton | W3-2 | 6-5-2 | Tokarski | Tokarski |
| zo., 14 nov. | - Toronto | L5-4 | 6-6-2 | Dell | Skinner |
| wo., 17 nov. | bij Pittsburgh | W2-1 | 7-6-2 | Tokarski | Tokarski |
| vr., 19 nov. | - Calgary | L5-0 | 7-7-2 | Tokarski | Dell |
| ma., 22 nov. | bij New York | L5-4 | 7-8-2 | Dell | Dahlin |
| di., 23 nov. | - Columbus | L7-4 | 7-9-2 | Dell | Thompson |
| do., 25 nov. | - Boston | L5-1 | 7-10-2 | Dell | Tokarski |
| za., 27 nov. | - Montreal | W4-1 | 8-10-2 | Tokarski | Tokarski |
| zo., 28 nov. | bij Detroit | L3-2 OT | 8-10-3 | Tokarski | Tokarski |
| di., 30 nov. | - Seattle | L7-4 | 8-11-3 | Tokarski | Murray |
| vr., 3 dec. | bij Florida | L7-4 | 8-12-3 | Dell | Hinostroza |
| zo., 5 dec. | bij Carolina | L6-2 | 8-13-3 | Subban | Olofsson |
| wo., 8 dec. | - Anaheim | L2-0 | 8-14-3 | Luukkonen | Thompson |
| za., 11 dec. | - New York | L2-1 | 8-15-3 | Luukkonen | Luukkonen |
| zo., 12 dec. | - Washington | L3-2 SO | 8-15-4 | Luukkonen | Luukkonen |
| wo., 15 dec. | bij Winnipeg | W4-2 | 9-15-4 | Luukkonen | Luukkonen |
| vr., 17 dec. | bij Minnesota | W3-2 SO | 10-15-4 | Luukkonen | Luukkonen |
| za., 18 dec. | bij Pittsburgh | L3-2 OT | 10-15-5 | Subban | Subban |
| di., 21 dec. | - Columbus | Uitgesteld | |||
| do., 23 dec. | - Colorado | Uitgesteld | |||
| vr., 24 dec. | bij Columbus | Uitgesteld | |||
| di., 28 dec. | - New York | Uitgesteld | |||
| do., 30 dec. | - New Jersey | L4-3 | 10-16-5 | Luukkonen | Thompson |
| vr., 31 dec. | bij New York | L4-1 | 10-17-5 | Subban | Okposo |
| za., 1 jan. | bij Boston | L4-3 OT | 10-17-6 | Luukkonen | Tuch |
| vr., 7 jan. | - San Jose | L3-2 | 10-18-6 | Luukkonen | Dahlin |
| zo., 9 jan. | bij Montreal | Uitgesteld | |||
| wo., 12 jan. | - Tampa Bay | L6-1 | 10-19-6 | Luukkonen | Miller |
| vr., 14 jan. | bij Nashville | W4-1 | 11-19-6 | Dell | Dell |
| zo., 16 jan. | bij Detroit | L4-0 | 11-20-6 | Dell | Dell |
| ma., 17 jan. | - Detroit | L3-2 OT | 11-20-7 | Dell | Skinner |
| wo., 19 jan. | bij Ottawa | W3-1 | 12-20-7 | Houser | Houser |
| vr., 21 jan. | - Dallas | L5-4 | 12-21-7 | Dell | Dahlin |
| za., 22 jan. | - Philadelphia | W6-3 | 13-21-7 | Houser | Krebs |
| wo., 26 jan. | bij Ottawa | L5-0 | 13-22-7 | Dell | Dell |
| zo., 30 jan. | bij Arizona | W3-1 | 14-22-7 | Anderson | Anderson |
| ma., 31 jan. | bij Colorado | L4-1 | 14-23-7 | Tokarski | Skinner |
| wo., 2 feb. | bij Vegas | L5-2 | 14-24-7 | Anderson | Hayden |
| vr., 11 feb. | - Columbus | L4-3 OT | 14-24-8 | Tokarski | Tuch |
| zo., 13 feb. | bij Montreal | W5-3 | 15-24-8 | Anderson | Skinner |
| wo., 16 feb. | - New York | W6-3 | 16-24-8 | Tokarski | Cozens |
| vr., 18 feb. | - Ottawa | L3-1 | 16-25-8 | Anderson | Anderson |
| za., 19 feb. | - Colorado | L5-3 | 16-26-8 | Tokarski | Thompson |
| ma., 21 feb. | bij Columbus | L7-3 | 16-27-8 | Anderson | Okposo |
| do., 24 feb. | bij Montreal | L4-0 | 16-28-8 | Anderson | Samuelsson |
| za., 26 feb. | bij St. Louis | L5-3 | 16-29-8 | Tokarski | Cozens |
| zo., 27 feb. | bij Dallas | L4-2 | 16-30-8 | Anderson | Eakin |
| do., 3 mrt. | bij Toronto | W5-1 | 17-30-8 | Anderson | Anderson |
| za., 5 mrt. | - Minnesota | W5-4 | 18-30-8 | Anderson | Skinner |
| zo., 6 mrt. | - Los Angeles | L3-0 | 18-31-8 | Tokarski | Tokarski |
| di., 8 mrt. | - Florida | L6-1 | 18-32-8 | Anderson | Hayden |
| vr., 11 mrt. | - Vegas | W3-1 | 19-32-8 | Anderson | Anderson |
| zo., 13 mrt. | - Toronto | W5-2 | 20-32-8 | Anderson | Hinostroza |
| vr., 18 mrt. | bij Edmonton | L6-1 | 20-33-8 | Anderson | Olofsson |
| za., 19 mrt. | bij Calgary | W1-0 OT | 21-33-8 | Tokarski | Tokarski |
| ma., 21 mrt. | bij Vancouver | W3-2 OT | 22-33-8 | Anderson | Anderson |
| do., 24 mrt. | - Pittsburgh | W4-3 SO | 23-33-8 | Anderson | Thompson |
| za., 26 mrt. | - Washington | L4-3 SO | 23-33-9 | Tokarski | Skinner |
| zo., 27 mrt. | bij New York | L5-4 OT | 23-33-10 | Anderson | Samuelsson |
| di., 29 mrt. | bij Chicago | W6-5 | 24-33-10 | Tokarski | Olofsson |
| do., 31 mrt. | - Winnipeg | L3-2 SO | 24-33-11 | Anderson | Girgensons |
| za., 2 apr. | - Nashville | W4-3 | 25-33-11 | Anderson | Thompson |
| zo., 3 apr. | - Florida | L5-3 | 25-34-11 | Tokarski | Okposo |
| wo., 6 apr. | - Carolina | W4-2 | 26-34-11 | Anderson | Anderson |
| vr., 8 apr. | bij Carolina | L5-3 | 26-35-11 | Anderson | Skinner |
| za., 9 apr. | bij Florida | L4-3 | 26-36-11 | Tokarski | Olofsson |
| zo., 10 apr. | bij Tampa Bay | L5-0 | 26-37-11 | Anderson | Tuch |
| wo., 13 apr. | bij Toronto | W5-2 | 27-37-11 | Anderson | Dahlin |
| vr., 15 apr. | - St. Louis | L6-2 | 27-38-11 | Anderson | Asplund |
| zo., 17 apr. | - Philadelphia | W4-3 | 28-38-11 | Anderson | Jokiharju |
| zo., 17 apr. | bij Philadelphia | W5-3 | 29-38-11 | Tokarski | Dahlin |
| vr., 22 apr. | bij New Jersey | W5-2 | 30-38-11 | Anderson | Olofsson |
| za., 23 apr. | - New York | W5-3 | 31-38-11 | Tokarski | Thompson |
| vr., 29 apr. | bij Boston | L5-0 | 31-39-11 | Tokarski | Asplund |
| za., 30 apr. | - Chicago | W3-2 OT | 32-39-11 | Tokarski | Mittelstadt |